areolar region injection: injection at the areola rather than at or superficial to the lesion involving similar volume and activity as the cutaneous injection method.cutaneous injection: intradermal or subcutaneous at the skin superficial to the lesion involving 0.2-1 mL containing 5.55-74 MBq (150-2000 μCi).perilesional (intraparenchymal, peritumoral) injection: on the side of the lesion and generally around the lesion, whether superficial or deep involving 3-4 mL containing 7.4-111 MBq (200-3000 μCi). To map drainage from the breast, multiple techniques are available, listed here in order of decreasing popularity 2: About 0.1-0.2 mL of tracer is deposited at each injection site, with a total activity of 7.4-37 MBq (200-1000 μCi) 1. Fine (25- or 27- gauge) needles are inserted nearly tangential to the skin, 5 to 10 mm from the lesion margin 1. Typically, two to four sites are injected. To map drainage from cutaneous lesions such as melanoma, radiotracer is injected intradermally around the lesion. Tc-99m antimony trisulfide colloid: Europe, Canada, Australia.Tc-99m nanocolloid human serum albumin: Europe.Commonly used agents vary worldwide due to regulatory approval status 1,2: RadiopharmaceuticalĬolloidal agents are used as these particles enter lymphatic channels and migrate to lymph nodes, where they are retained by macrophages. Lymphoscintigraphy is a nuclear medicine technique to visualize regional lymphatic drainage, especially for mapping sentinel lymph nodes, from a site of radiopharmaceutical injection.
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